To assess the effects of cadmium on heart and lung in acute and subacute intoxicated rat, different doses of cadmium were administered into male Sprague-Dawley rats by single intravenous injection. At 12, 24, 48, 168 and 672 hours after Cd
injection,
tissue cadmium concentration and histopathological findings were examined.
Cardiac Cd concentration tended to increase in dose-dependent pattern(r=0.8255, n=73, p<0.01), and was reached to peak within 12 hours after injection and then reduced with time. Pulmonary Cd concentration also tended to increase in
dose-dependent
pattern(r=0.8239, n=74, p<0.01), and the concentration was reduced with time. A significant correlation between cardiac and pulmonary Cd content was observed (Cd Lu=-0.0019+0.4783 Cd H, F=191.3, r=0.8556, n=72, p<0.01).
Myofibrillolysis and contracture of myofiber were shown in heart tissue and alveolar septal wall thickening and inflammatory cell infiltration in intersititial tissue were observed in lung tissue. These Cd-induced histopathologic findings were
aggravated with time and increasing dose.
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